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Mean performances of the whole group in both fixed-interval and extinction schedules were very similar to those described previously [ 32] and thus, it appears that an interaction with previous training had a negligible influence.
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A concurrent extinction schedule was present on the wrong lever.
A concurrent extinction schedule was in effect on the alternative lever.
A concurrent extinction schedule (never associated with any cue light) was present on the wrong lever.
Only hyperactivity during an extinction schedule revealed an association with impaired working memory.
An extinction schedule (unassociated with any cue light) was present on the wrong lever.
Reduced working memory performance was only observed in hyperactive rats in an extinction schedule.
A concurrent extinction schedule, never associated with the cue light or a reinforcer, was present on the wrong lever.
ADHD, attention deficit-hyperactivity disorder; CHX, delay-discounting task; EXT, extinction schedule; FCN, fixed consecutive number schedule; FI, fixed interval schedule; LOW, subgroup of rats with low scores; INT, subgroup of intermediate rats; HIGH, subgroup of rats with high scores; FDR, False Discovery Rate; ANOVA, analysis of variance; GLM, General Linear Model.
Furthermore, a sensory discrimination deficit (i.e., perception of light changes between the fixed-interval and extinction sessions), can be excluded since all rats stopped responding at the beginning of an extinction schedule, indicating they perceived that the light was no longer present.
Perinatal exposure of rats to an environmental PCB mixture (Kostyniak et al. 2005) resulted in a decrease in the ratio of reinforced:nonreinforced lever presses on a DRL schedule (Sable et al. 2009), as well as higher rates of responding during an extinction schedule after DRL testing (Sable et al. 2006).
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CEO of Professional Science Editing for Scientists @ prosciediting.com