Exact(4)
To facilitate extinction, rats will be administered an HDAC inhibitor (HDACi) following nonreinforced exposure to the conditioned context.
Extinction: Rats with DMS and DLS lesions and their controls progressed onto an extinction paradigm.
Following extinction, rats received two baseline sessions, with parameters identical to the pre-extinction baseline.
Throughout extinction, rats were connected to the tethers and lever responses were recorded but produced no consequences (i.e., the cocaine infusion pump was not activated, and the light and tone cues were withheld).
Similar(56)
In the extinction context, rats that received a CS + US trial before extinction exhibited higher levels of conditional freezing than animals in all other groups, which did not differ from one another.
To exclude the effect of repeated NaBut injections themselves on morphine-CPP in the absence of extinction session, rats received injection of either NaBut or vehicle for 8 days.
Previous studies have shown that spike bursting in the IL is a neural correlate of extinction in rats [27], [36].
Following 14 additional extinction sessions rats were tested for yohimbine-induced relapse (1 hr duration, no reward, yohimbine [2 mg/kg, 1 ml/kg, intraperitoneal, 30 min prior to start of session], with cues).
In a rodent study, suppression of adult hippocampal neurogenesis increased vulnerability to addiction and increased resistance to extinction in rats trained to self-administer cocaine (Noonan et al., 2010).
With repeated extinction sessions rats seem to learn that in this phase of the task no reward will be given and extinguish much more rapidly with each successive probe test.
However, differences in bursting between the two groups emerged in the extinction session: DELAY rats exhibited higher levels of bursting than IMMED rats.
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