For a Property they could be (i) general endpoint and experimental protocol, (ii) particular experimental protocol (for locally measured values), (iii) literature sources (for externally retrieved values).
When comparing VT values provided by built-in software with externally measured values in cycles with expiratory additional leaks, three software tools (T, PB 560 and V50) significantly underestimated VT, with values ranging from -48 ± 6.7% (T) to -29 ± 7.5% (V 50).
As shown, mean deviation from the externally measured values never exceeded 10%, with an intraclass coefficient value of > 0.975 for all tested software.
When using the CDE Curation Tool, the values may be drawn from EVS terminologies or other externally defined value sets.
When comparing the VT values provided by the built-in software of the commercial ventilators with the externally measured values in cycles with inspiratory additional leaks, it was found that the commercial software tested significantly overestimated VT.
Thus, although low values of q2 almost certainly indicate that the model is not expected to be predictive externally, high values of this parameter alone also provide no guarantee that the underlying models can be used for the reliable external prediction.
Autonomy implies the ability to make decisions under a personal rather than an externally imposed value system.
The built-in software of the other two commercial ventilators, however, showed only a minimal deviation from the externally monitored values in the leakage.
The decision rule of the ICER estimate requires knowledge as to whether the estimate is below or above an externally set value which is the maximum decision makers will be willing to pay for an extra unit of health gain.
Assuming externally reported values are accurate and the model assumptions are reasonable, lower than expected concentration estimates would suggest a tendency to over report exposures, while higher than expected concentrations would suggest underreporting.
