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Figure 2 Receiver operator characteristic curve and external validation performance (Pipeline Pilot model).
Abbreviations: Matthews Correlation Coefficient – MCC, Receiver Operator Characteristic – ROC. Figure 3 ROC curve and external validation performance (KNIME model).
Variety specific models correctly identified 75 85% of immature tomatoes and 82 86% of mature green tomatoes in internal cross-validation, however external validation performance decreased when applied to predict maturities in a cultivar external to the training set.
Plot representing the 13-fold cross-validation results, in terms of AUC, for the three targets (AhR, ER-LBD and HSE) comparing different best performing models (3NN, 5NN, 7NN, RF, NB, and PNN) [28] Fig. 3 External validation performance results of classifiers.
In order to keep the independency between the external validation performance and the consistency degree, none of the external validation data sets are used here.
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At external validation, the performance of the developed model is validated in a different data-set.
External validation of performance was assessed using receiver operator characteristic (ROC) analyses and the Youden index to identify optimal thresholds for differentiation.
Table 4 summarises the results of the external validation of the performance of both models.
On temporal and external validation, overall discrimination performance was good with polytomous c-indexes between 0.57 and 0.64.
The need to increase the awareness for harmonization initiatives and external validation of assay performance is one of the general common findings of both initiatives.
Data on primary tumours diagnosed between 2007 and 2008 in 43 Dutch hospitals were used for external validation of the performance of the nomogram (n = 12,308).
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com