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It is found that the PVPy-modified PNIPAAm hydrogels displayed faster response to the external temperature changes than the control PNIPAAm hydrogel.
Compared to control PNIPAAm hydrogel, the PNIPAAm-b-PVPy hydrogels displayed an accelerated response to the external temperature changes in terms of deswelling and reswelling tests.
Thermoresponsive cell culture dishes that show controlled cell adhesion and detachment following external temperature changes, represent a promising application of thermoresponsive surfaces.
The morphology of the hydrogels was observed by scanning electron microscopy (SEM), their thermal property was characterized by differential scanning calorimetry (DSC), thermogravimetric analysis (TGA) and deswelling/swelling kinetics upon external temperature changes.
The influence of the pendant PDMAEMA grafts on the properties of the resulted hydrogels was examined in terms of morphology observed by scanning electron microscopy (SEM), thermal property characterized by differential scanning calorimetry (DSC) and shrinking/swelling kinetics upon external temperature changes.
While the PNIPAAm-g-PS copolymer networks were subjected to the swelling experiments, it is found that the PS block-containing PNIPAAm hydrogels significantly exhibited faster response to the external temperature changes according to swelling, deswelling, and reswelling experiments than the conventional PNIPAAm hydrogels.
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The external temperature changed among 20 25 °C, and the medium temperature changed among 25 30 °C.
The thermoresponsive PNVCL surface exhibited a hydrophilic/hydrophobic alteration with external temperature change, which enabled the thermally modulated attachment and detachment of cells.
For example, developmental rate in ectotherms is contingent on external temperature, and changes in developmental rate can in turn alter the relative allometries of different morphological and physiological traits [ 1].
As possible external signals, temperature change is one of useful stimuli due to its low invasiveness to living body system and simple site-selective application using medical devices.
Thin PIPAAm hydrogels on the biomaterials surfaces exhibit rapid and reversible phase transitions and act as switching sequences to regulate the interaction between the surfaces and biological materials by external temperature-induced changes.
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