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We sent separated pituitary tissue for pathologic examination, one for a local pathologist and other to an external pathology laboratory.
The feasibility of this strategy may be hindered by limited microbiological investigations and involvement of multiple external pathology laboratories.
A 20 ml fasting blood sample is collected by a nationally accredited external pathology laboratory (also blinded to the adolescent's treatment allocation) which has many collection sites in the study region.
Adolescents attended an initial appointment with a parent/carer to assess baseline anthropometry and pubertal stage, to complete demographic questionnaires, and to arrange fasting venipuncture at an external pathology laboratory.
However, the following report from external pathology laboratory indicated that the pituitary tissue carried a large area of lymphoplasmacytic infiltration with quite prominent mature plasma cell population and storiform collagenous fibrosis.
Each of the ten selected FFPE samples was re-embedded in two twin blocks, and the six selected cases were then re-embedded again by an external pathology laboratory (IPP, Paris, France) for anonymisation.
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The samples were analysed at an external (clinical pathology accredited) laboratory [28].
This was a case wherein complications caused by failure to control diabetes induced skull-base osteomyelitis, which was accompanied by an infected jaw joint, ear pain, otorrhea resulting from external ear canal pathology on the affected side, and mouth-opening limitations.
It was subject to external accreditation by Clinical Pathology Accreditation (UK) to ISO15189 and provided a clinical biochemistry service to the NHS trust, local community and mental health trusts and 150 GP practices.
Over the years, much like its predecessors, ELSA research has been confronted with a number of internal and external challenges, or even "pathologies", as Wickson et al. ([2014]) have phrased it.
Given that the ancestral vertebral shape would not have been adapted for bipedalism, individuals whose vertebrae are towards the ancestral end of the range of shape variation can be expected to suffer disproportionately from external load-related spinal pathologies.
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