Sentence examples for external leaflet from inspiring English sources
external leaflet of the cell membrane.
Phosphatidylcholine and sphyngomyelin cholinophospholipids are primarily located within the external leaflet of the cell membrane.
Phosphatidylcholine (PC) and sphyngomyelin (SM) cholinophospholipids are primarily located in the external leaflet of the cell membrane (ECM).
PS is normally present on the inner leaflet (Kunzelmann-Marche et al., 2000), whereas neutral phospholipids (e.g., phosphatidylcholine) are found on the external leaflet of a membrane bilayer (Phillis et al., 2006).
Thus, sialidase activity reveals to be a potential tool to control dynamically the structural properties of the membrane external leaflet of living cells, influencing both the morphology of the close environment and the extent of interaction among active molecules belonging to signalling platforms.
Other lipids, such as sphingomyelin, appear to be synthesised at the external leaflet.
Moreover, the apoptotic effect of imatinib (10 μM, 50 μM) after 24 h of exposure was demonstrated as evaluated by translocation of phosphatidylserine to external membrane leaflet and by increased activity of caspase-3.
Those included integral membrane proteins, as well as others anchored to the internal or external PM leaflet, but also the PH domain of PLC-δ1, which is not directly anchored to the PM, but transiently recruited to its cytoplasmic face through interaction with membrane phospholipids [39].
As translocation of phosphatidylserine (PS) to the external membrane leaflet is one of the earliest features of apoptosis, early apoptotic cells can thus be identified by the Annexin-V-FITC/PI double staining assay.
In an infection with La, amastigote forms display PS on their external membrane outer leaflet, a typical apoptotic feature of multicellular organisms without necessarily leading to parasite death.
It has been reported that COBRA localizes at the external plasma membrane leaflet through a glycosylphosphatidylinositol (GPI) moiety [ 22].
