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Finally, we demonstrate that our method makes it possible to use external imputation templates to analyze rare variants imputed into existing GWAS datasets.
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For a superadditive TU game, the Shapley value is an internal and external stable imputation, and for NTU games, it is formulated in [32],[32].
By external stability, an imputation outside a stable set J is unlikely to be attained.
If the probability of data being missing is associated with variables measured in the study and is not influenced by unobserved external factors, multiple imputation is an appropriate method to avoid bias that may occur in complete case analysis due to selective missing of data.
Impute: impute: Imputation for microarray data.
Knowledge assisted approach integrates domain knowledge or external information into the imputation process, which may significantly improve the imputation accuracy [ 12], such as Fuzzy C-Means clustering (FCM) [ 20] and Projection Onto Convex Sets (POCS) [ 21].
The model thus predicts the intuitive result that increasing the size of a reference panel (internal or external) leads to fewer imputation errors.
We used a random sample of 3,317 scrapie negative animals genotyped at codons 136, 154 and 171 and we made inferences on the position 141 by multiple imputations, using external data.
The relative accuracy for imputation using the external panel compared to the internal panel is quantified by E[ S2 − S1].
Until now there is little experience with the use of multiple imputation in an external validation setting.
Our external validation study also used multiple imputation, with 20 imputed datasets, to deal with the missing data.
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CEO of Professional Science Editing for Scientists @ prosciediting.com