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Analysis of the effect of external hormones on gynecological cancer must take into account the lag time of cancer development.
Several factors expressed in the microenvironment by epithelium and mesenchyma play key roles in regulating this process, apart from other external hormones and growth factors secreted by reproductive glands [ 43].
Analysis of the effect of external hormones on colon cancer must take into account the lag time in cancer development, although it is difficult for observational studies to account sufficiently for time-dependence.
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In addition, they were differentially affected by external hormone application, suggesting their different regulation and expression during meristem formation and maintenance and lamina growth.
All observations refer to specimens in breeding conditions, without external (hormone) stimulus.
We did not examine women using hormone contraceptives, since this external hormone intake might alter emotion processing.
Furthermore, to exclude external hormone influences only females without oral contraceptives or any hormone treatment were included.
Its formation of sex phenotype is also influenced by environmental factors such as water temperature and external hormone [ 22].
This suggests that cervical mucus monitoring is an accurate and efficient way for women to prospectively identify ovulation without need for an external hormone monitoring device.
Although the effect of external hormone supply on genes belonging to NO3- assimilation pathway or sensing system has already been documented, our results propose a new dimension of interaction at the transcriptional level between hormonal and NO3- signaling.
Development of mOGCT may involve the combined effect of genetic alterations or predisposition and disadvantageous environmental factors such as exposure to maternal hormones, external endocrine disruptors, or adverse lifestyle-related factors that disturb the cells' normal biochemistry.
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