Interestingly, these two treatments stimulated PI hydrolysis to a lower extent in control females than in control males, suggesting an even greater amplification by PRS in females (Fig. 6C,D).
In the neurogenic region of the hippocampus, BrdU+ cells were not found to be double labeled with Iba-1 to any measurable extent in control fed rats without LPS or in spirulina fed rats with LPS.
While total copper accumulation was higher in cells over-expressing either copper uptake gene, the relative efficiency of accumulation was decreased to a similar extent in control and over-expression cell lines when Syx5 was suppressed.
Treatment with IGF-1 modestly increased TSC2 levels to a similar extent in control and IR-deficient cells.
Furthermore, RO-256981 reduces NMDA calcium response to a similar extent in control and CXCL12-treated neurons.
TLR2 and TLR4 protein expression was localized in single, scattered cells, both in pSS patients and, to a lesser extent, in control patients, showing a distinct staining pattern.
Conversely, the D2R antagonist haloperidol, that activates striatopallidal (indirect) pathway, induced catalepsy to a significantly greater extent in control littermates than in Pdcl cKO mice.
As all the above electro-heterogeneous inclusions are seen, to a much lesser extent, in control cells, we here term them collectively 'debris'debris
However, TPA induced Erk phosphorylation to the same extent in control cells as in cells with downregulated PKCε (Fig 6C), indicating that Erk is not a crucial mediator of the PKCε effect.
Further, TLR4 and TLR9 in vivo activation induced elevated levels of circulating anti- and proinflammatory cytokines in CreLysM Casp8fl/fl and control mice (Fig. 3c and Additional file 1: Figure S3), but to a much greater extent in control mice in response to TLR4 activation (Fig. 3c).
