To this extent a complete test-stand system, based on custom PCI cards and specialized software, has been developed.
In 2005, data from 8,800 neuroblastoma patients were analyzed to develop a comprehensive classification system based on age, extent of disease (or stage), MYCN status, and several other biological and genetic factors.
Regarding TS expression, the immune reaction was graded as negative (score 0) or positive, in a semiquantitative, 3-tier system based on the extent of reactivity (score 1, 1 10% reactivity; score 2, 11 50% reactivity; and score 3, >50% reactivity) [ 21].
Expression of ERCC1 was quantified using a visual grading system based on the extent of staining (percentage of tumour cells) graded on a scale of 0 3 (0 = no staining, 1 = weak staining, 2 = moderate staining, and 3 = strong staining) [ 25].
Expression of EGFR was quantified using a visual grading system based on the extent of staining ( percentage of positive tumor cells graded on scale of 0 to 3: 0, none; 1, 1-30%, 2, 31-60%, 3, > 60% ) and the intensity of staining (graded on a scale of 0 to 3: 0, none; 1, weak staining; 2, moderate staining; 3, strong staining ).
Histopathologic examination of all biopsies was performed by a single pathologist, who graded endoscopic specimens and assigned a lesion severity score for each dog by using a standardized and previously described histologic grading system, based on the extent of architectural disruption and mucosal epithelial changes [ 12, 13, 17, 18].
Expressions of CXCR7, CXCR4 and HIF-1 α were quantified using a visual grading system based on the extent of staining (percentage of positive tumour cells graded on scale from 0 to 3: 0, none; 1, 1 30%; 2, 31 60%; 3, >60%) and the intensity of staining (graded on a scale of 0 3: 0, none; 1, weak staining; 2, moderate staining; 3, strong staining).
A severity score was assigned for each dog, by using a standardized and previously described histologic grading system, based on the extent of architectural disruption and mucosal epithelial changes [ 12, 13], as has recently been proposed by the WSAVA for diagnosis of gastrointestinal inflammation [ 14].
c Layering at the inner ring (center at 24°24′E, 24°34′N) and d layering exposed north of the Oasis impact crater (center at 24°24′E, 24°39′N) Fig. 5 Sketch map with extents of geomorphologic units and paleodrainage system based on highest resolution ALOS PALSAR-2 polarimetric data.
In their seminal description of over a 1000 open fractures, Gustilo and Anderson developed a classification system based predominantly on the extent of soft tissue damage.
