Due to the absence of similar studies in other tumour entities, e.g. lung cancer, it remains unclear to what extent the reproducibility of FMISO will be affected by the lack of rigid immobilization and the presence of respiratory motion.
These explicit recommendations are most likely to improve pathological assessment of disease extent and reproducibility of grade of DCIS and may improve detection of invasive disease.
A measure of the extent of the reproducibility of the sugar profiles obtained from the pigmented systems with respect to the unpigmented ones can be expressed by calculating the correlation coefficients.
When expression data for each replicate were plotted against each other, RPKM values were observed to be adequately reproducible, though expectedly, the extent of reproducibility was slightly less in genes with low expression [ 17].
When conducting pharmacoepidemiological studies, it has been recommended that at least two cohorts be evaluated to establish the extent of reproducibility.
Benefits of a recombinant expression system include control over the expressed protein sequence, control over extent of posttranslational modifications, and reproducibility of culturing conditions and hence protein composition [ 11– 16].
To determine the extent of interobserver agreement and intraobserver reproducibility of the subjective determination of visual field progression with achromatic automated static perimetry in eyes with glaucoma, and to determine the impact of access to Glaucoma Progression Analysis (GPA) data on interobserver agreement.
It should be noted, however, that the reproducibility of MVC was influenced, to some extent, by the motor learning effect [38].
However, these differences did not seem to affect the reproducibility of the measurement to any large extent as indicated by the similarity in CV values across platforms.
More effort is needed to determine the reproducibility of these results, and to determine to what extent they are relevant for clinical practice.
