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The extent of vision loss depends on how much of the retina is affected and whether the macula is involved.
Membrane-bound FasL triggered photoreceptor cell death, while soluble FasL exhibited neuroprotective effects, indicating that enzyme-mediated cleavage of FasL determines, in part, the extent of vision loss following retinal detachment.
This trial would aim to establish the exact role of the FUSION approach, and to validate if it can be used as an alternative to monthly regimens without compromising the extent of vision gain, even in the current population of patients in daily clinical practice who may present with very good levels of vision.
The function of FasL was dependent upon the form of FasL expressed: mFasL triggered photoreceptor cell death, whereas sFasL protected the retina, indicating that enzyme-mediated cleavage of FasL determines, in part, the extent of vision loss following the retinal detachment.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com