Exact(3)
Our African data suggest that we would need to sequence the var genes of hundreds of genomes to observe the full extent of var DBLa diversity in one local population (Figure S1).
We set out to determine i) the extent of var gene diversity in three African sites, ii) the level of var gene differentiation across the African continent, and iii) the population structure of var genes in Africa.
The extent of var diversity in local African parasite populations compared to PNG and South America is consistent to that seen for genome-wide SNPs, microsatellites and mitochondrial genome diversity data, albeit with greater diversity in the var system [8], [43], [44].
Similar(57)
DOI: http://dx.doi.org/10.7554/eLife.00093.007 Two recent large-scale studies aimed at assessing the extent of local reservoirs of var genes in five epidemiologically and geographically distinct P. falciparum populations (Barry et al., 2007; Chen et al., 2011) provide us with new knowledge on the distribution of var genes in parasite genomes.
Furthermore, the extent of overlap among the var repertoires will determine cross-immunity in the host population to distinct parasite genomes.
Correct spelling of var.
The capitula of var.
Chromosome numbers of var.
Planted specimen of var.
minor, 7 cells of var.
Representatives of inflorescence of var.
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