http://ClinicalTrials.gov has several thousands of trials registered, and consequently the real extent of inadequate trial registration may be under- or overestimated.
The lawsuit, filed Wednesday in a North Carolina court, comes 14 months after a scandal erupted at Duke that finally exposed the extent of the trial's problems: in July 2010, Duke oncologist Anil Potti, whose work was central to the trial, admitted that he had embellished his resume and later resigned.
National registers of ongoing clinical trials, which could provide data regarding the extent of seed trials and phase III randomised trials, are generally either non-existent or not accessible.
We hypothesized that a positive relationship exists between the extent of a trial's interactions and treatment success.
The real extent of inadequate trial registration may be under- or overestimated.
Statistical evidence for heterogeneity between trials was assessed using the Q-test, and the I index was used as an estimate of the extent of between trial variability.
The extent of unpublished trials evaluating retention strategies is unknown; however, this review includes several unpublished trials and we made an effort to capture UK-based unpublished trials through our survey and research contacts.
We limited ourselves to these seven journals because we thought it would be unwise to commit resources to a systematic review without having a much better idea of the type and extent of pre-trial testing done in complex intervention studies.
The extent of collaboration within trial teams between researchers from different disciplines, such as social scientists and epidemiologists, is another important aspect.
The in-depth process evaluation practices were a group of practices in the QICKD trial which received the same intervention as the main trial practices but were also observed so we could learn about programme fidelity (i.e. the extent to which the intervention ran as planned) and intervention exposure (i.e. the extent to which members of trial practices were exposed to the intervention) [ 19, 15].
