The SNPs and INDELs detected in ER and ISO12 were found to be distributed throughout the extent of the S288c reference genome, albeit with varying peak density (Additional file 1: Figure S1).
A cross tabulation visualized per vignette the extent of agreement, between the reference labels of the case vignettes and the final sense of reassurance or sense of alarm judgment (item 7) given by the study population (see Table 7).
Furthermore, the extent of bias toward the reference allele increased with the number of neighboring differentiating sites.
These two characteristics are especially important in the production of biosimilars, where achieving the correct extent of similarity to the reference molecule is a great challenge.
Although the design of the TC, to a large extent, inherits that of the reference IFMIF-EVEDA (Engineering Validation and Engineering Design Activities) TC, design justifications are required to solve the existing major open issues such as cavitation of the lithium flow, activation and maintainability of key components, and etc.
Other factors that affect the accuracy of imputation include levels of linkage disequilibrium (LD) in the population, the degree of similarity between the reference population and the test population and, to some extent, the size of the reference population [ 7- 10].
To check whether and to what extent the choice of the reference sample had an impact on CNS calling, we decided to choose two different reference samples, each comprising 106 parental pairs.
This estimate, which is based on Sanger sequencing (272,172 ESTs from cDNA clones), next-generation transcriptome sequencing (7.4 Mb GS-FLX and 59.5 Mb of Illumina GA-II), and genomic sequencing (1.7 Gb GS-FLX), provides a good basis on which to judge the extent of our reference transcriptome.
After the appearance of an anomaly, we need to evaluate the probability that it will be a precursor to a large earthquake; i.e., we need to forecast whether the probability in a space time zone will increase to an extent, relative to that of the reference probability.
The reliability of the GEBVs depends to a very high extent on the size of the reference population.
The discharge potential curves may be separated into two segments from 0 ≤ x ≤ ∼0.51 and ∼0.51 ≤ x ≤ 1.00, where x is the dimensionless extent of discharge referenced to the rated cell capacity.
