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In practice, more general applicability of our GIS-enabled approach is limited by three factors: particular differences in the extent of technical focus on GIS among sites; availability of relevant data; and variability in geographic and demographic organization among sites.
Before proceeding to tests for differential methylation, we tested the reproducibility of our 450 K array data by assessing the extent of technical variation at CpGs within five genomic regions using independent locus-specific EpiTYPER PCR-based assays in 30 55 individuals from our cohort.
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The Fountain Scene in Act I introduced a Lucia who went about her business with such apparent ease that the audience could have been excused had they failed to recognise the extent of her technical achievement.
"As the Dublin rules do not foresee the suspension of transfers by the receiving member states, the commission has asked Hungary for immediate clarification on the nature and extent of the technical failure, and on the measures taken to remedy the situation".
An applicability score evaluated metrics based on cost of data collection, probable spatial extent of applicability, technical complexity, and indicator responsiveness.
It would take weeks to figure out the full extent of the technical problems that the administration was facing after which the president was left with the choice of delaying the law for a period of time or forging ahead with the same 6-month enrollment period.
The statement from Nasdaq contradicted a Wall Street Journal report earlier Tuesday that said Nasdaq would have "pulled the plug" on the historic IPO had it known the extent of the technical problems that would follow during the day's trading.
However, the system and reagents are expensive, thereby limiting the extent of necessary technical and biological replication [ 13].
Bearing in mind the prospect of increasing demand for measurements of estradiol and other sex steroids at low concentrations, the nature and extent of the technical difficulties connected with performing such determinations should be carefully considered and addressed.
"The issues nowadays are unbelievably pluralistic," said Dr. Daniel Kevles, a science historian and professor at Yale. "There's hardly an issue you can think of that doesn't turn to some extent on technical knowledge".
The extent of medical-technical progress is as a rule assessed by the proportion of the total volume of sales accounted for by new or improved products and techniques, R&D expenditure or the number of patent applications.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com