Sentence examples for extent of target from inspiring English sources
The effectiveness of siRNA was characterized by measuring the IC50 values in cell culture and the maximal extent of target suppression.
Total RNA was extracted from remaining nematodes using TRI reagent (MRC, Cincinnati, OH) and used for qPCR to determine the extent of target gene knockdown.
This study in a working population may have underestimated the extent of target organ disease in the general population because people with debilitating effects from target organ damage would be under represented in the working group.
The extent of target gene knockdown (β-catenin), as well as downstream targets, MITF, Myc (β-catenin target genes), BCL2 (MITF target gene) [45], were assessed at protein levels by successive Western blotting with antibodies to β-catenin as a control.
As siRNA-mediated knockdown studies are dependent on the extent of target knockdown, we decided to validate the above findings by using genetically TG2-depleted MEF cells [ 33].
It should be noted that knock-down was not optimised for the other 18 genes and thus Tn levels may reflect partly the extent of target depletion.
In cultured cells, the extent of targeted gene knockdown by survivin siRNA-expressing DNA nanocassettes using the uPAR-targeted nanoparticle delivery system was similar to that achieved with SV40-nuclear localization signal- (NLS-) mediated internalization of the QD-survivin siRNA nanocassettes.
For example, the composition of a particular sample will affect KcPM,N and KcPM,S as well, because both constants depend on the extent of target-dimerization which is a function of the concentrations of the reacting species in the hybridization solution [ 1].
This extent-of-conversion target line has been inserted in Figure 2, with the value of 32% conversion chosen to minimize inaccuracies arising from linear interpolation between data points by placing the intersection-points on each curve as close as possible to actual data points.
We, therefore, examined the extent of gene target downregulation as a function of the number of binding sites for these seeds in target transcripts.
In most cases, the range extent of the target to be detected is much larger than the range resolution of radar.
