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Moreover, different organic solvents were used to enhance the extent of sensitization [23].
In order to check whether altering the electronic conjugation between these two units causes reduction in the extent of sensitization, we have synthesized a pyridinyloxy-fluorescein dye PyFlEt and attached it to two designed ruthenium nitrosyls through the pyridine-N donor of the pyridinyloxy-end.
The findings are based on data from 10,000 Americans who were part of the National Health and Nutrition Examination Survey 2005-2006, which examined number of allergens as well as extent of sensitization to allergens.
Pearson test revealed no significant correlation between the extent of sensitization (as measured by the change in mean velocity between acute and challenged groups) and the extent of reinstatement (r = −0.33, p>0.05) (see figure 7a).
However, when testing these three compounds, we found that none of them reproduced the extent of sensitization observed with PIK-75 co-treatment.
Marked sensitization was again observed, with only a slight decrease in extent of sensitization (~2 fold) compared to a 24 h concurrent treatment.
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In seasonal pollen-related disease, there are variations between subjects in the extent of pollen sensitization, individual variations in exposure to pollen even within a set area because of lifestyle differences, and variations between different areas in pollen counts and weather patterns.
Thus, the rate and extent of P2X7 sensitization determine the outcome of the receptor activation.
The current study demonstrates that the propensity to reinstate a CPP is not associated with either the extent of original CPP or psychomotor sensitization, suggesting a dissociation of these components of addictive behaviour.
Moreover, we addressed whether the suppressive effect of capsaicin on LA-LTP might be mediated via CB1 receptors, and to what extent, sensitization of TRPV1 can influence the capsaicin-induced effect on LA-LTP.
To assay cell sensitization and the extent of apoptosis induction after DNA damage or oxidative stress, an equal number of siRNA-treated cells were subcultured in complete medium containing 400 µM H2O2 for 3 h followed by a recovery period in complete medium for 21 h.
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