Brain distribution, in terms of extent, was restricted as indicated by the 0 4 h AUC (brain ECF /AUC (plasma, unbound) ratios (Kpuu) values of 0.3 and 0.2 after IN and IV administration, respectively (which is an underestimation for the IN administration, as unanticipated, the elimination half-life was absorption-rate limited such that AUC 0 ∞ values could not be adequately determined).
Tumors were evaluated radiologically on the following parameters: location (dominant and secondary sites of involvement), relationship to midline, circumscription, extent of edema and restricted diffusion, and the presence of cysts or necrosis, hemorrhage, and enhancement.
Having this amount of data, we performed various types of analysis to test different hypotheses, although the sample size of the study to some extent restricted the strength of these further analyses.
Technical possibilities of these modification methods, however, are, to a large extent, restricted by peculiarities of a vitreous state with characteristic effects of natural physical aging, functional non-reproducibility, and thermodynamic instability in view of high affinity to chemical reactivity.
That, to some extent, restricted the range of actions that we had.
Together, these data suggest that, like its Drosophila counterpart, human miR-200c∼141 inhibits cell growth of PC-3 cells at large extent by restricting ligand-mediated activation of NOTCH signalling.
Similarly, the extent of sandhi modification was restricted in Middle Indo-Aryan.
Endowments are not discretionary slush funds; they are made up to a considerable extent of funds that are restricted to particular uses.
However, the spatial extent of seabird influence seemed restricted to reefs close to the island within 100 to 400 m from the shore.
The extent of the labeling is restricted to the cell bodies and proximal dendrites of projection neurons and the tracer does not enter axon collaterals [90] [92].
