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Using this arbitrary segregation, we noted a very strong effect and near perfect correlation of C5 allelic status and extent of replication of C. albicans in kidney with two notable exceptions (Table 1).
Our results show that the Wlds mutation does not alter the extent of replication of TMEV in retina or the axonal transport of the virus from retinal ganglion cells to neurons of the LGN.
However, whether the extent of replication stress can affect the probability of neoplastic transformation remains elusive.
Altogether, our data show that the extent of replication stress is determined by folate deficiency in a concentration-dependent manner.
The extent of replication observed between our two cohorts is comparable to that initially reported by Lunnon et al. [ 42] between their samples and other independent cohorts.
The extent of replication and transmissibility of a virus in the host animal has a major influence on the magnitude of outbreaks.
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It therefore seems reasonable to suggest that the extent of replication-competency testing currently required in some jurisdictions could be reduced.
Altogether, our results show that in vivo development of cancer is mediated by a combination of genetic and non-genetic factors that affects the extent of replication-induced genomic instability.
Geminin also limits the extent of DNA replication during the cell cycle by binding and inhibiting the essential replication factor Cdt1 [27].
In addition to regulating cell differentiation, Geminin also limits the extent of DNA replication to one round per S phase by binding and inhibiting the essential replication factor Cdt1 [11].
Within the oncolytic virus field, the extent of virus replication that is essential for immune stimulation to control tumor growth remains unresolved.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com