These scores capture the extent of read clustering in a ChIP-seq experiment in organisms whose genomes have similar size and structure to those of mammals.
The RSC metric captures well the extent of read enrichment in vertebrate genomes similar in size and structure to humans, which this study focuses on.
Finally, the currently available QC metrics were designed and are best suited for TF data that produce highly localized "point-source" occupancy (as they quantify the extent of read clustering in the genome).
The resulting plot has one ("phantom") peak corresponding to the read length and another peak corresponding to the average fragment length; the height of the fragment-length peak is highly informative of the extent of read clustering in the library and, in turn, of the success of a ChIP-seq experiment.
Of the studies for which control datasets were available, 32.8% (45 of 123) contained at least one highly clustered control with a score of 1 or 2, and 29.2% (40 of 123) contained a control with a score of 0. Thus, control datasets surprisingly often exhibit a high extent of read clustering similar to that of ChIP-seq datasets.
Because next-generation sequencing technologies are improving and longer read lengths are becoming possible, we explored the extent of read-mapping bias for read lengths of 50 and 100 bp.
This "police state" license of the Patriot Act could affect me, to the extent that my choice of reading material is adversely interpreted by law enforcement.
And it's no surprise that students increasingly don't want to read — to the extent that the rejection of reading implies the rejection of what reading has become in the hands of educators whose mandate is to train students rather than to cultivate their aesthetic passions.
Some eBook readers enable free reading with a bookstore and loan of items.[9] If that appeals to you, realize that the extent of free reads and loans might be highly dependent on the particular bookstore.
Regardless of location or reason, contradictions are confusing for users, and require them to investigate the data more fully, often to the extent of re-reading the original paper in which the result was published.
The regulation of infB which is downstream and co-transcribed with moderately expressed TF gene nusA (RCBS = 0.46579), is complex and is thought to be the result of auto regulation of the extent of the read through at upstream terminators by moderately expressed nusA.
