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T-cell hybridomas do not require co-stimulation and therefore pMHC-II levels should directly correlate with the extent of antigen presentation.
By using MHC class I peptides, DC-to-splenocyte ELISPOTs can be used to evaluate the extent of cross-presentation.
The results of the present study confirm that there were large differences among hospitals in age distribution, extent of deprivation, mode of presentation, extent of tumour spread at presentation and pathological stage.
To assess the interrelationship between extent of adrenarche at presentation in girls with precocious adrenarche (PA) born appropriate for gestational age and their growth pattern, pubertal course and adult height.
This within group difference is probably reflective of the extent of haemorrhage at presentation.
Clinical outcome is dependent upon extent of disease at presentation, also known as tumor stage.
These delays may affect extent of disease at presentation and outcomes of treatment.
The clinical extent of disease at presentation was based on TNM group staging (UICC 1978).
It is therefore likely that the extent of cancer at presentation, as measured by traditional staging methods, does not fully explain the poorer prognosis of these patients.
However, the anatomic TNM staging system, based on histopathology and extent of disease at presentation, has reached its limit in providing critical information that may influence the strategy of treatment.
Despite the fact that malignant melanoma is considered as radioresistant, radiation therapy would be planed if complete surgical excision is not possible due to the extent of disease at presentation [ 2, 24].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com