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By 63 days post-infection, the extent of pathology was reduced in all experimental groups.
Moreover, these results also suggest that the HN878 inocula size determines the extent of pathology seen in the lungs of infected animals (Figure 2 versus data described in the text for low dose HN878 infection).
In summary, each of 7 lung lobes was scored from 0 5 depending on the number of lesions and extent of pathology observed, 0 being no pathology and 5 being extensive gross-coalescing lesions.
We have therefore conducted the present study in a larger set of 30 PD patients to allow in depth analysis of enteric pathology throughout the colonic SMP, and to correlate the extent of pathology with motor symptoms and constipation.
The BMI, co-morbidity, and extent of pathology are affected by complex sex and gender interaction as well.
Incidence and extent of pathology present in neural tissues or flight muscle, were noted (n > 15 animals per genotype).
Similar(41)
71 If T2DM has an impact on cognition only through accelerating AD pathology, the extent of the pathology should be similar when cases of cognitive impairment with similar levels of severity are compared cross-sectionally, either pathologically or using amyloid imaging.
This latter study also showed that overexpression of Aβ40 in a well-characterized AD transgenic mouse model (Tg2576) caused a reduction in the extent of amyloid pathology and that overexpression of Aβ42 increased the extent of amyloid pathology in the same model.
Recent progress in the development of these tracers is enabling the noninvasive assessment of the extent of tau pathology in the brain, eventually allowing the quantification of changes in tau pathology over time and its relation to cognitive performance, brain volumetrics, and other biomarkers, as well as assessment of efficacy and patient recruitment for antitau therapeutic trials.
A substantial number of neurologically unimpaired subjects even at a very old age display only sparse to modest extent of neurodegenerative pathology and only a subset of the middle-aged subjects with HP tau pathology in the LC and entorhinal cortex seem to develop a dementing disorder with aging.
The high agreement here was also related to the fact that the assessors only had to evaluate the absence or presence of Aβ-IR pathology and thus the results were not influenced by the previously reported variability in the assessment of the extent of the pathology [ 6].
More suggestions(17)
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