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It has become apparent in some recently reported trials, e.g. IPASS [ 3] and ICON7 [ 4], that gross breaches of the PH assumption can and do occur even to the extent of observing crossing survival curves, where a local estimate of the log HR changes sign over time.
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Extreme heterogeneity was identified and the extent of observed reduction in consumption over time was greater in studies undertaken in Anglophone countries, with single gender study participants, and without special targeting by age.
Filter and bacteria cell-free culture filtrate assays demonstrated that the extent of killing observed is significantly less than that observed in the direct killing assay.
The extent of apoptosis observed was similar to that observed following adenoviral gene transfer of TRAIL and FasL.
In contrast, the extent of killing observed via the filter assay is still significantly less than that observed in the direct killing assay (p<0.0001) implying that secreted toxin is incapable of independently causing worm mortality.
While this may represent the level of apoptosis observed with KOS (Figs. 1– 4), this seems unlikely because the extent of release observed by indirect immunofluorescence with KOS at 12 hpi was minimal (Fig. 4).
The changes in the extent of reaction observed between individual experiments, and thus the attendant error bars, were consistent with those observed during the kinetic analyses of other ribozymes.
It is interesting that the degree of filamentation observed in bacteria that are actively expressing the DX gene is less extensive than the extent of filamentation observed in other bacterial systems [44].
The tissue selectivity and the timing of drug administration were suspected of being the underlying factors driving the variability and extent of malformation observed in humans born with thalidomide-related limb defects in the late 1950s and early 1960s.
The extent of growth observed were indicated as ++++ (full growth), +++ (strong), ++ (moderate), + (weak) and − sensitive) signs.
Many planetary geologists are skeptical that this theory would explain the extent of erosion observed on Mars.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com