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Robert E. Eckhardt, an evolutionary biologist at Penn State University who remains skeptical, said in an e-mail message that supporters of that interpretation "have ignored, overlooked, discounted or misrepresented the extent of normal and abnormal variation in morphological structure and biomechanical function that exists in members of our own species, Homo sapiens".
Currently, the total extent of normal mtDNA variation within the multitude of haplogroups from the various continental populations remains unknown.
The level of m-THPC in other tissues is also important in PDT to predict the possible extent of normal tissue damage.
It will be particularly important to clearly establish the extent of normal variation for cases where the difference between normal and diseased gene expression profiles is subtle.
The latter factor could be in relationship with the extent of normal brain tissue damage caused by the tumour as has been demonstrated after strokes.
We present an approach that predicts the number of SPs that coexist in a tumor, the size of the SPs in the tumor bulk, the mutations that mark each SP and the extent of normal cell contamination.
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A prerequisite in the investigation of vascular alterations in the dura mater is a thorough understanding of the normal organization of dural vasculature in mice and of the extent of its normal biological variance.
The extent of our normal daily emergency workload as a major trauma receiving centre, combined with a reasonable major incident plan and the flexibility of all members of staff, were also major contributory factors.
In contrast, inside intact domiciles in the field, individuals are recorded living more than 60 days (Gilbert JDJ, unpublished data), though the extent of their normal lifespan is currently unknown.
When the cells are grown to greater confluency, they show a more epithelial-like cobblestone morphology (Fig. 2), although not to the extent of other "normal" breast cell lines.
In the Bmpr1 DKO OPC cultures that were untreated or treated with BMP4, the cells differentiated to the extent of the normal cells, as we have previously shown (See et al., 2007).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com