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The in vitro extent of kill correlated well with the in vivo extent of kill for all 5/5 triplets, thereby reinforcing the exquisite efficacy of BDQ and PA824 (57, 57).
Table 1 shows the extent of kill observed for each drug when tested at its MIC, i.e., a FIC of 1.
Similar(57)
Ill-health, increasing arthritis and an unhappy domestic life may have combined to make him thoroughly miserable but not to the extent of killing himself.
While Mr. Bush cautiously accentuated the progress that he feels is occurring, the Israeli emphasized the extent of killing that the Israelis were suffering at the hands of the Palestinians.
In contrast, the extent of killing observed via the filter assay is still significantly less than that observed in the direct killing assay (p<0.0001) implying that secreted toxin is incapable of independently causing worm mortality.
Viable bacteria (CFU) were counted and the rate and extent of killing were determined by plotting CFU/ml against time (D'Arezzo et al. 2012; Lee et al. 2008).
The mean extent of cell kill was 34±12 and 11±11% for the respective compounds.
It may be that patients' OS and DFS were not so much determined by the extent of cell kill induced by chemotherapy.
The extent of cell kill at the maximum drug concentration was high for all of the drugs (>85% see Table 1), demonstrating that the majority of cells within the TSP were drug-sensitive.
Administering either misonidazole or RSU 1164 before, or hydralazine after, the chemotherapeutic agents melphalan, cyclophosphamide or the nitrosourea CCNU, increased the extent of cell kill in both the KHT sarcoma and RIF-1 tumour.
The data in Table 2 (see also Table S2 in the supplemental material) show the extent of bacterial kill obtained in the case of each triplet at its most potent synergistic ∑FIC index value, where the individual drug concentrations were at FICs of ≤0.5, i.e., half their MICs.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com