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In addition, this study suggests that the extent of grey matter loss is related to both a history of early adverse events and circulating cortisol levels.
Additionally, we assessed whether the level of kif21b expression correlated with the extent of grey matter demyelination in MS patients.
In MS patients, kif21b correlated with the extent of grey matter demyelination (Spearman's rho = 0.31, p = 0.03).
White matter changes dominated the extent of grey matter changes, which might argue against Wallerian degeneration as the major cause of white matter affection in myotonic dystrophies.
We found that the individuals who had been using cocaine for longer periods of time, had greater extent of grey matter volume reduction in the anterior and middle cingulate gyrus, middle frontal cortex (orbital part), rectus gyrus, supplementary motor area, superior temporal gyrus, insula, cerebellum and in the left caudate (r = −0.75, P > 0.001; Fig. 2).
The fact that white matter changes by far dominated the extent of grey matter changes in myotonic dystrophy types 1 and 2 might further argue against Wallerian degeneration as the major cause of white matter alterations as formerly postulated (Ota et al., 2006).
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With increasing distance rostral or caudal to the lesion centre, the extent of visible grey matter damage tapered off rapidly and at only 2 mm from the centre of the lesion the spinal cord appeared visibly undamaged (see Fig. 1E).
In contrast when patients with attenuated symptoms were compared to controls the extent of the grey matter loss was markedly less.
Until now, only few studies have investigated the extent and localization of grey matter (GM) involvement.
To determine the effects of fluorinated glucocorticoids on the occurrence and extent of ischaemic-like excitotoxic grey and white matter cerebral injuries in an animal model.
Sporadic Creutzfeldt-Jakob disease is considered primarily a disease of grey matter, although the extent of white matter involvement has not been well described.
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