GGT1 was studied to ascertain the extent of expression in GCT and clinical response, because it has been found to be essential for the nephrotoxicity of cisplatin in animal models; however, its activity was not required for therapeutic effect (290).
Based on these earlier findings and their ability to promote fracture healing and bone fusion, we studied the above-mentioned osteoinductive BMPs for their eventual presence, cellular localization, and extent of expression in the peri-implant synovial membrane-like interface tissue around aseptically loosened THRs, in control synovial membranes and in MSCs and osteoblasts produced from MSCs.
Although these two numbers are not directly comparable since the mouse experiments are more controlled than the human-chimpanzee comparison and thus have more power to detect difference, the extent of expression differences induced in the liver by a change in diet is impressive.
It would be interesting to look for the extent of surplus expression in other maternally expressed genes, especially those essential to embryonic survival, like tube, and compare them to the expression profiles of zygotically expressed genes.
To obtain insight in the extent of expression of inhibitory regulators of immunity in patients with active TB, peripheral-blood-mononuclear-cells (PBMCs) and plasma were obtained from 54 TB patients and 29 healthy blood donors from Chittagong, Bangladesh.
cxcr4b is expressed in dHb neuronal precursors around the time at which they generate postmitotic neurons [ 23], and the timing, asymmetry, and extent of expression are not affected in 32 hpf (hours postfertilization) mutants.
As a first step to test the extent of expression of the transgene in embryos, we generated 4n (tetraploid) wild type <-> mRFP1 ES cell derived chimeras [ 21], exactly as described previously [ 3].
For example, tumor cells in breast carcinomas that vary in extent of expression of estrogen receptor appear to be more likely to fail systemic therapy than those tumors that exhibit more uniform expression of the receptor (Sklarew et al. 1990).
He also caught up with a leading social media campaigner, to find out the extent of online freedom of expression in China.
Our results reveal that changes in the extent of expression and the type of proteoglycans being expressed are tightly associated with tissue remodeling after renal transplantation.
In comparison to uninjected WT embryos at 55 hpf (Figure 3A), induction of bmp2b by heat shock at 48 hpf in tg(hsp70 bmp2b) resulted in increased intensity and extent of hepcidin expression in the liver and foregut (Figure 3B) by whole mount in situ hybridization, while treatment with dorsomorphin from 28 55 hpf (Figure 3C) abrogated hepcidin expression.
