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Our results reveal that changes in the extent of expression and the type of proteoglycans being expressed are tightly associated with tissue remodeling after renal transplantation.
The eCB-involved differential modulation of synaptic activities probably results from the differences in the extent of expression and function of the CB1 receptor at the two synapses.
Indeed it is intriguing that such an extent of expression and activity related to starch pathways are present in sugar beet tap-root without starch produced.
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A co-expression network derived in this manner indeed shows a robust correlation between the extent of expression correlation and the degree of functional association, in part because of its high dimensionality.
Thus, it was of interest to determine the extent of expression partitioning and overlap between the two grn gene classes during development by RT-PCR and to compare these patterns to those known for the mammalian counterpart.
Among the list of DEGs (see Table 1) we selected 13 genes according to the extent of expression changes and their potential relevant functions (e.g. transcription factors, G-protein coupled receptors or neuropeptides) (Table 2).
GGT1 was studied to ascertain the extent of expression in GCT and clinical response, because it has been found to be essential for the nephrotoxicity of cisplatin in animal models; however, its activity was not required for therapeutic effect (290).
In summary, Survivin is expressed in the majority of pancreatic cancers and the extent of expression correlates strongly with proliferative and apoptotic functions of malignant cells.
This approach allowed us to correct for any confounding effects that might be caused by significant individual gene expression differences among subjects at baseline, by normalizing the extent of expression at Weeks 8 and 12 with the patient's own baseline expression and increasing the reliability of the findings by utilizing Week 12 expression patterns to confirm those that occurred at Week 8.
cxcr4b is expressed in dHb neuronal precursors around the time at which they generate postmitotic neurons [ 23], and the timing, asymmetry, and extent of expression are not affected in 32 hpf (hours postfertilization) mutants.
Despite known instances where RAGE is up-regulated in disease, the full extent of RAGE expression and the molecular mechanisms that regulate its expression and subsequent downstream effects have not been adequately evaluated.
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