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Molecular docking study validated the binding pattern and extent of binding of compounds 3 and 4 with the target enzymes.
In addition, the maximum extent of binding of GS14dK4 can also vary considerably with phospholipid composition in a parallel fashion.
In nearly all cases, the extent of binding of the noble gases follows the trend xenon > krypton > argon.
The molecular docking studies were conducted in order to get insight the binding pattern and extent of binding of compounds with the target enzymes.
The extent of binding highly depends upon the nature, hydropobicity of the copolymer molecules, length of the hydrocarbon tail and nature of the head group of the surfactant.
Interaction of the phosphonic acid derivative (0.11 mmol) of n-butylacrylamide phosphonate with hydroxyapatite (0.15 or 0.30 mmol calcium ions) showed 80 and 95% extent of binding of the phosphonic acid whereas those values for acrylic acid were 47 and 64%.
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The kinetics of AFB1 binding to these DNAs showed similar initial rates but the extents of binding to the PLC and hHC DNAs seemed to be slightly higher.
Yet an additional benefit of this means of characterization is the ability to identify specific lectins whose extents of binding might also directly correlate with metastatic capacity.
Among the lectins that were observed to bind to these cell lines, four (namely, RCA-I, Triticum vulgaris agglutinin (WGA), Wisteria floribunda agglutinin (WFA) and Sambucus nigra agglutinin I (SNA-I)) were found to show noticeably different extents of binding to different cell lines.
However, the actual extent of Cbl binding is debated, and inefficient binding of Cbl could also explain the low lysosomal degradation of ErbB2 (Chan et al. 2004; Dankort et al. 1997; Levkowitz et al. 1996, 2000; Olayioye et al. 2000).
Thus, the net circuit loss of a drug may represent a balance between binding to circuit components versus extent of protein binding.
More suggestions(16)
degree of binding
range of binding
length of binding
size of binding
relevance of binding
intensity of binding
magnitude of binding
implication of binding
breadth of binding
amplitude of binding
rate of binding
importance of binding
significance of binding
measurements of binding
proportion of binding
extent of mandatory
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