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In conclusion, the association of pulmonary emphysema with NSIP (and, to a lesser extent, observations relating to a crazy-paving pattern) provide support for cigarette smoking as a pathogenetic factor in a subset of NSIP patients.
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However, the metrics that are most sensitive to local patterns are least likely to exhibit consistent scaling relations with increasing extent (observation scale).
Globally, SWOT would substantially improve on GRDC observation extent: SWOT observation of 100 m (50 m) rivers will allow discharge estimation in >60% of 50,000 km2 (10,000 km2) river basins.
Over time the number and extent of observations and phenomena studied increase.
Predatory lady beetles were more abundant and aphids were lower in fields with hedgerows, up to 200 m into fields, the maximum extent of observations.
Although it cannot be thoroughly documented due to the limited extent of observations, seasonal changes in pCO2 in the Southern Ocean are approximated by using the data for under-ice waters during austral winter and those for the marginal ice and ice-free zones.
The traditional view of the placement of ice during the LGM derived in large measure from the landmark Climate: Long range Investigation, Mapping, and Prediction (CLIMAP) project of the late 1970s and early 1980s that estimated ice extent from observations on sea surface temperatures, glacial ice, and albedo (CLIMAP 1981, Denton and Hughes 1981).
In order to see to what extent our observations transfer beyond the BL31 cell line, we investigated the effect of EBNA3B deletion in LCLs, as EBNA3B is known to be dispensable for B cell immortalisation [12].
It therefore remains unclear to which extent the observations can be translated to normal STN function.
These data confirm and extent earlier observations derived from Ussing chamber experiments showing increased paracellular permeability in colon tissue of IBS patients [ 194].
Results also highlight a requirement for better appraisal of the deposit extent, with observations of locations where the deposit is absent as important as those defining substantial thickness.
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