15– 19 Nitrogen-based ligands have been used extensively to trigger these cycloaddition reactions.
However potential toxicity of IgA could be a problem, since PMNs, expressing high levels of FcαRI are abundantly present in blood and may be triggered extensively.
The difference in pH values existing between healthy tissues (pH 7.4) and the extracellular environment of solid tumors (pH 6.5 6.8), as well as between the cytosol (pH 7.4) and endosomes (pH 5 6), has been extensively utilized to trigger the release of drugs into a specific organ or intracellular compartment.
Statins have been extensively shown to trigger apoptosis of cell lines derived from haematological malignancies, including acute myelogenous leukemia and multiple myeloma[ 7, 9].
Viruses may stimulate some of the early events in SLE pathogenesis (Ramos-Casals et al, 2008), and Epstein-Barr virus (EBV) is the most extensively studied trigger (Poole et al, 2006; Posnett, 2008).
The signaling pathway triggered by TSLP has been extensively studied, and upregulation of the cytokine itself is linked to the pathogenesis of numerous Th2-related diseases, including atopic dermatitis, asthma, allergic responses, as well as certain types of cancers.
In contrast, the other isomer demonstrates a highly red-shifted electroluminescence (53 nm), which was supposed to be intrinsically resulted from the extensively rearranged molecular structures at charged states triggered by the external electronic field during the device operation.
Since its identification to date, the transduction signaling and gene expression profile triggered by GPER have been extensively characterized.
The biosilicification process in these organisms has been extensively studied, and is hitherto believed to be triggered via hydrolysis of silicic acid by cationic proteins such as silicateins [8] [15] and polycationic peptides such as silaffins [8] [13], [16], [17].
This principle is extensively used in functional MRI to assess brain activity triggered with exercise or other external stimuli.
