Sentence examples for extensively shown in from inspiring English sources

Our first aim was to determine if the increases in extracellular excitatory amino acid levels is mediated by a VRAC-like pathway, as has been extensively shown in vitro.

Direct incorporation of BM-progenitor cells has been extensively shown in diverse models [24] but the low and variable frequency at which BM-progenitors are found incorporated into vessels is suggestive of an indirect (possibly paracrine or justacrine) role during the neo-angiogenesis processes.

Moreover, it has been extensively shown in humans that obesity correlates with bone metabolism (reviewed by [ 35, 36]).

As such, impaired fat oxidation in the fasted state was extensively shown in obese insulin-resistant and type 2 diabetic individuals [ 27].

However, although direct molecular evidences of D2R-A2AR oligomerization have been extensively shown in heterologous expression systems (Cabello et al., 2009; Canals et al., 2003; Ciruela et al., 2004; Kamiya et al., 2003), to our knowledge it has still not been definitely proved, despite certain data pointing to it, in native tissue (i.e. striatum).

The fact that the MST is a neighbourhood graph that can well approximate the main network information offering a general summary of the network topology—has been extensively shown in different applications (Cannistraci et al., 2010; Shaw and Jebara, 2009; Shieh et al., 2011), and in our case, this can be particularly useful for denoising the information present in PPINs.

Increased MT synthesis has been extensively shown to occur in response to many metals, in both short-term laboratory exposures and in chronically exposed wild fish and it is the most consistent and sometimes only, mechanism of metal tolerance in fish [e.g., refs (14, 15 and 32− 34)].

While the role of animals in the emergence of clinically important, antimicrobial-resistant strains has been extensively shown (e.g., in Salmonella spp ., the role of aquatic environment as a reservoir of antimicrobial-resistance genes is less established (16 – 216).

The involvement of TLR4 in immunity to B. pertussis vaccine has been extensively shown and specific SNPs in the promoter region of the TLR4 gene influencing the antibody response to the pertussis (PT) vaccine have been identified [ 126, 127].

Hormone pathways, ET and JA, have been extensively shown to be involved in resistance against necrotrophs and thus it was postulated that these pathways would be induced in Eucalyptus (Table  1).

This approach, applied in this study, differs markedly from commonly employed stand-alone stigma reduction programs, which have not been extensively shown to decrease stigmatizing attitudes in adolescents [ 48, 49].