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While most loci and SNPs discovered in Europeans have been extensively replicated in European and East Asian populations, replication in African populations is much less frequent.
This concern, however, is being allayed with the advent of techniques such as Dr Song's mobile-sampling method.Another worry is that, despite the fact that most twin studies have been extensively replicated, they may be subject to systematic flaws.
Here, we address this question for the size and shape of Drosophila melanogaster wings in an experimental design with extensively replicated and fully controlled genotypes.
This four-factor model was extensively replicated and widely accepted in previous studies.
Following Radloff's (1977) factor analytic procedures, this four-factor structure of the CES-D has been extensively replicated and widely accepted in subsequent studies [ 9, 10].
These genes include extensively replicated genes such as BDNF, which is not only shown to be associated with adult obesity but also with childhood obesity [ 89].
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After 12 24 h after cell entry Brucella extensively replicates without restricting basic cellular functions or inducing obvious damage to cells [6].
Since encephalogenic flaviviruses such as WN, JE and SLE viruses initially expand in dendritic cells and macrophages and then extensively replicate in the brain, ideally siRNA needs to be delivered to both these cell types.
Although many positive results were reported, most are never replicated extensively.
After 7 to 10 days about 2 weeks sooner than required to count CFU fluorometry reveals whether M. tuberculosis bacilli in each well have replicated extensively enough to reduce a resazurin dye added for the final hour.
Moreover, a recent paper by Siontis et al. [ 28] shows that a good number of the associations detected in non-GWAS classical association studies (mostly those extensively studied) have been replicated in recent GWAS (41 of 291 with a p < 10-7).
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