Sentence examples for extensively implicated from inspiring English sources

Aberrant activation of oncogenic signal transducer and activator of transcription 3 (STAT3) protein signaling pathways has been extensively implicated in human cancers.

In addition to their classical transport function, NPCs have now been extensively implicated in transcriptional gene regulation and in DNA damage repair via interactions with the underlying chromatin.

After its discovery as a key controller of metabolic function, leptin has been later extensively implicated in additional functions including important modulatory activities on the innate and adaptive immune response.

The amygdala was used because it has been extensively implicated in anxiety-like behavior.

The tachykinins have been extensively implicated in the initiation and progression of lung disease processes such as bronchitis and asthma [16] [19].

We examined the bottom-up influence of these regions on an area extensively implicated in semantic processing – the middle temporal gyrus [9], [20], [21] – as well as the top-down influence from inferior frontal gyrus to this semantic processing region.

The activation of these four signaling pathways, which have been studied extensively and implicated in early heart induction during embryonic development [13], is consistent with their role in promoting CD in MSCs and myocardial regeneration in infarcted hearts treated with EGJ/cardiogenin.

We find that several cell-autonomous effects observed when ESCRT function is disrupted are mediated by c-Jun N-terminal kinase (JNK), a member of the mitogen-activated protein kinase (MAPK) family, which has extensively been implicated in programmed cell death [20] and is misregulated in many types of mammalian cancers [21] [25].

The MYC oncogene is an extensively studied gene, implicated in various cellular processes including growth, proliferation, loss of differentiation and cell death.

Age-related changes to subcutaneous tissue have been extensively documented and implicated as affecting facial appearance [13] [16], and probably accounted for some of the remaining variation in the data.

Whereas the induction of cell proliferation by arsenite has been extensively studied, the events implicated in regulating the apoptosis of skin cells exposed to arsenite remain largely unknown.