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The efficacy of the treatments has been extensively estimated under experimental conditions, mainly through randomized clinical trials.
Like P16INK4A [ 8], the relationship between hypermethylation of APC with cancers has also been extensively estimated [ 9] and APC promoter hypermethylation in NSCLC has been reported as an effective biomarker for diagnosis [ 10, 11].
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Although most celebrities keep quiet about their money, in a 1996 Los Angeles Daily News interview, Caine talked about his finances quite openly and extensively, estimating that he had amassed a $24 million fortune.
The fate and impact modelling relied extensively on estimated data, given that most of these compounds have little or no experimental fate or ecotoxicity data available, as well as a limited reported occurrence in effluents.
The higher Mr fractions of Pln.198 did not appear to be glycosylated as extensively, with estimated GAG chains of 3-13 kDagainin assuming glycosylation at each of the three SGD regions in rhPln.198.
They continue to be used extensively to estimate changes in prices over time and are also used to measure differences in costs among different areas or countries.
Finally, autosomal microsatellites have been used extensively to estimate levels of genetic diversity [9] [11].
Nest counts have been used extensively to estimate great ape population densities [1] [3].
Although a single gene tree has been used extensively to estimate the species tree, evidence has been shown that gene trees may differ in topology from each other and the true tree [19].
Registry data, both in the UK 1 and internationally, 10 11 have been used extensively to estimate time to revision.
This methodology has been used extensively to estimate the incidence of other underreported diseases that are rarely confirmed by laboratory testing, such as influenza [ 15– 17].
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