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However, it is becoming extensively clear that many oncogene-activated signalling pathways converge towards an adaptation of tumor cell metabolism to provide energy and essential biomolecules required for the rapid cell division [ 4– 6].
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Its lower reach (in Sierra Leone) flows through a densely populated mangrove swamp area that has been extensively cleared for rice cultivation by the Temne people.
Existing networks of linear remnants present a low cost opportunity for regional scale conservation across extensively cleared agricultural landscapes.
This deterioration of the dominant trees in the patch is symptomatic of remnant native vegetation over vast areas of Australia's extensively cleared wheat sheep regions.
The contiguous forest landscapes of the Brigalow Belt Bioregion in Australia's subtropics, known as 'the western hardwood forests' are thought to be important for biodiversity conservation through the provision of continuous habitat features in an otherwise extensively cleared region.
If the Amazon, with its great diversity of plant and animal life today, was once extensively cleared and supported a large population of prehistoric people, that bodes well for the forest's powers of recovery.
In addition, evidence of differentiation of soil fungal phylogenetics between nearby but isolated remnants suggests that conserving soil fungal diversity requires conservation of host habitats over their entire (remaining) range, and indicates previously unseen consequences of tree loss from extensively cleared landscapes.
Pine forests were extensively cleared by urban developers and the lumber industry in the 1930s and 1940s.
The Endangered Heritiera globosa has the most restricted distribution in this region (extent of occurrence<5,000 km2) as it is only known from western Borneo, where its patchily distributed, primarily riverine habitat has been extensively cleared by logging activities and for the creation of timber and oil palm plantations.
It is extensively cleared by the hepatobiliary system and no dose adjustment (0.5 2 µg/kg/min) is required for initial dosing.
Impaired renal function can reduce the clearance of drugs that are extensively cleared by the kidneys, thereby increasing the incidence of exposure-dependent side-effects.
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