Sentence examples for extensive variant from inspiring English sources

We established an extensive variant annotation data source for the identification of pathogenic variants.

Despite extensive variant filtering and prioritization we are still left with unmanageable numbers of potentially causative mutations in many probands, which we were unable to further refine.

OVA incorporates an extensive variant filtering step available for VCF files, including support for multi-sample VCF files with multiple affected/unaffected patients that can be often available to researchers studying rare genetic diseases.

Despite the proven utility of, and high diagnostic demand for, NGS-based assays, interpretation and filtering of the extensive variant lists is currently a labor-intensive and cumbersome task, and hampers the implementation of WES in routine diagnostics [ 3, 4].

High levels of multiplexing and consistent genome representation can be achieved by utilizing enzymes with complex recognition motifs, while enzymes with simple motifs may better serve experiments requiring extensive variant identification.

Incorporating familial/pedigree information not only provides powerful filtering options for the extensive variant lists that are usually produced by HTS but also allows valuable quality control checks, insights into the genetic model and the genotypic status of individuals of interest.

The extensive variants, coupled with their abundance, provide a powerful network for the virus to regulate its own biology as well as the host response.

Building upon the conserved core components of the RNA silencing machinery such as DCLs and AGOs, plants have evolved extensive variants of these components, especially AGOs.

A comparison with existing ESTs indicates even more extensive gene variant clusters in O. marina CCMP1788.

For the most extensive gene variant clusters, contigs were predominantly highly overlapping and biased toward the 3' end of mRNAs (e.g. Figure 4c).

Likewise, the occurrence of extensive expressed gene variants, seemingly common in most dinoflagellates has the potential to result in extensive discrepancy between sequence and qPCR bases approaches; particularly if qPCR assays co-amplify extensive gene variant families.