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HuES8, in particular, showed extensive variability in the generation of CD45+ cells between experiments (Fig. 2C).
That is, they have by design ignored the context of human ecology and the extensive variability in the human genome.
However, the extensive variability in the length and position of SCNAs makes the problem of identifying recurrent aberrations notoriously difficult.
This conclusion was confirmed by proteomic analysis, which demonstrated extensive variability in the glycoproteins purified on GalMBP (supplementary Table III).
Interestingly, previous studies point to extensive variability in the presence and the exact patterns of skew among eukaryotes.
Extensive variability in the magnitude of r2 at a given genetic distance was detected reflecting the wide local variation in the extent of LD across the chromosomes.
Similar(45)
Inference on the C-terminal extension was more difficult, due to extensive variability in this region; dog shares the two amino acids extension with cat, cow, and alpaca, although with minor differences in these two latter species (fig. 1 C).
Key amino acids in the PUM-HD of several of these proteins are conserved with those of animal and fungal homologs, whereas other plant Puf proteins demonstrate extensive variability in these amino acids.
We noted extensive variability in both the timing and magnitude of BD3 induction across individuals.
Extensive variability in both the timing and magnitude of BD3 induction across individuals was noted and was not predicted by skin pigment phenotype, suggesting that BD3 induction was not influenced by epidermal melanization.
Due to the complexity of the folate cycle as well as the extensive variability in response to the drug in clinical practice, it is hypothesized that genetic factors may contribute to differences seen in distinct patterns of MTXglu concentrations intracellularly, which might further impact patients' responses to MTX.
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