Knockout mouse for Sod2 does not survive due to extensive cardiomyopathy underscoring the importance of O2− removal in normal cardiac function (Li et al., 1995).
This reveals an extensive interface underscoring the importance of a stable interaction between these two proteins to allow Pan3 to supply Pan2 with substrate RNA for efficient mRNA deadenylation.
"I spent a lot of time with him in the Situation Room going over difficult issues," she said, implicitly underscoring her extensive political experience.
This result indicates that the MEK1 T55delinsertionertion was preexisting in a subset of the pre-treatment tumor, thereby underscoring the extensive heterogeneity of these tumors.
The aryl hydrocarbon receptor (AhR) ligands TCDD, PeCDF, and PCB126 produced very similar global gene expression profiles that were unique from the nonAhR ligand PCB153, underscoring the extensive impact of AhR activation and/or the resulting hepatic injury on global gene expression in female rat liver.
Extensive evidence has been generated underscoring the relevance of the stroma in carcinogenesis (Radisky and Radisky, 2007).
Nor is he going to other large countries like Mexico, Colombia and Argentina, underscoring that his visit is limited to nations without extensive influence or the capacity to offer much of a major economic partnership.
Organism differentiation required an extensive suite of additional molecular assessments not available at that time, thus underscoring the difficulty of diagnosing M. tuberculosis complex agents correctly and the inability of most national health laboratories to do so.
Our findings also underscore the extensive transcriptional plasticity in response to the social environment and reinforce the importance of uncovering the molecular and cellular factors and constraints governing olfactory function and the neurogenomic consequences of experiencing different social olfactory cues.
Their analysis underscores the extensive sharing of genetic risk loci across this spectrum of disorders, and the fact that most of these loci can be mapped to a few shared biologic pathways, including those related to innate immunity, immune signaling, T-cell differentiation, cytokines and chemokines.
