In embryos and early post-natal mice, TIMP-3 is expressed at sites of extensive tissue remodeling such as developing bony structures and somites, lung, skin, hair follicles, ear, external regions of the eye, cornea, choroid plexus as well as interdigit webs [43].
Most solid tumors possess characteristics that are not observed in normal tissues, such as extensive angiogenesis and hence hyper-vasculature, defective vascular architecture, impaired lymphatic drainage/recovery systems, and greatly increased production of a number of permeability mediators [ 1].
The pathologic examination revealed that tumor tissues had rich vessel distribution, extensive necrosis and invasion surrounding normal tissues, such as muscular tissue and subcutaneous tissue.
The more extensive availability of mesenchymal stem cells (MSCs) from various tissues, such as bone marrow5, adipose tissue6, synovial membrane7 and other tissues, compared with that of original chondrocytes, as well as the higher proliferative capacity of MSCs, highlight the attractiveness of MSCs as cell substitutes in cartilage regeneration.
Tissues such as liver and kidney had extensive capillary network, therefore, it might make large quantities of drugs accumulate in liver and kidney.
However, extensive evidence documenting low rates of remobilization of Cd from leaves towards growing sink tissues, such as grain, roots, and young expanding leaves [ 35, 36, 39, 40], suggests that Cd has limited phloem mobility in wheat.
If colorectal cancer has spread to surrounding tissues such as those of the uterus, prostate, liver, kidneys, or bladder, more extensive surgery may be required to remove all or part of these organs.
Soft biological tissues, such as cartilage or intervertebral disks, 2) are based on hydrogel matrices comprising extensive physical cross-links.
The list of nuclear receptors expressed in a circadian fashion is extensive 36 with more than half of the NRs detected displaying tissue-specific cycling, frequently in metabolic tissues such as liver, skeletal muscle, white adipose tissue (WAT), and brown adipose tissue (BAT) (Table 1).
ECM-rich tissues such as the VF mucosa are challenging to analyze using proteomic assays, primarily due to the extensive crosslinking and glycosylation of many high Mr ECM proteins [16], [17].
