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Thus, after extensive T cell culture only a subgroup of predicted peptides can be verified as natural epitopes.
Haploidentical transplantation, with extensive T cell depletion to prevent GvHD, is associated with a high incidence of infection-related deaths.
The higher number of B cells in TCR-TgA mice could present antigen to T cells more effectively and led to a more extensive T cell activation).
It is not clear how this data compares with published work showing strong and extensive T transcripts until the end of axis elongation.
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An additional strategy, for which proof of principle has been obtained in pilot clinical trials26, involves the non-myeloablative induction of mixed chimaerism with a regimen that includes extensive T-cell depletion of the initial HCT.
"More Extensive Test Needed for Colon Cancer, Studies Say" (news article, July 20) points out that a colonoscopy, which Medicare and most insurers don't cover unless a patient is at high risk, can be costly.
In contrast to the anti-CD25 mAb treatment, with mild autoimmune manifestations, germline FoxP3 mutations or general depletion of Treg performed in conditional FoxP3 mutants leads to lymphadenopathy, extensive T-cell activation and severe autoimmune lymphoproliferative disease in neonates and adults [35], [39].
Indeed, the synovitis of RA is characterized by extensive T-cell activation [ 47].
A striking use of extensive T-box regulation in ABC transport was observed in L. plantarum.
In TLTs of NOD, RIP-LTα, and RIP-CXCL13 transgenic mice, extensive T-zone stromal cell networks were identified based on the following surface phenotype: podoplanin + CD31− CD31−.
They do not possess extensive T-tubular systems (Mackenzie et al. 2001, 2004) but instead have prominent transversely oriented SR, Z-tubular, elements.
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