Sentence examples for extensive substitutions from inspiring English sources

We found that the entire region examined can endure extensive substitutions without affecting transcriptional activation by v-Myb in budding yeast.

Extensive substitutions of adenosines in this sequence with cytidines had no effect on P1 usage as can be seen in the oligo-dT primed RT PCR analysis presented in Figure 3B (compare lanes 1 3).

Substitutions at L3 and L5 did not yet turn Epo into a Pla-like invasin, which required more extensive substitutions both at the surface-exposed part of the protein and the membrane-embedded N-terminal region, the β1-strand.

So far, a single serotype of human HAV has been recognized, which suggests that severe structural constraints occur in the capsid that prevent the more extensive substitutions necessary for the emergence of a new serotype.

In augite there can be extensive substitution of aluminum for tetrahedral silicon.

Nearly all natural garnets exhibit extensive substitution; solid-solution series some complete, others only partial exist between several pairs of the group.

Despite the extensive substitution, FNoTNc retains both the three-dimensional structure and the cell adhesion activity of FNfn10.

Extensive substitution of bromodeoxyuridine for thymidine in "viral" DNA does not photosensitize the biological activity of the virus.

This is in line with the finding that extensive substitution was required to induce invasiveness into Epo.

A CipA mutant lacking the C-terminal XDocII module was constructed by homologous recombination, but required the use of a modified cipA allele in which DNA repeats were removed by extensive synonymous substitutions [ 18].

The analysis of functional loci has revealed that loss of the other two guiding functions for E3 results from extensive nucleotide substitutions and indels, disrupting the snoRNA/substrate RNA base-pairing potential of the 5' and 3' regions in the snoRNA.