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Comparisons of the patterns of pore-lining residues and mapping of functional determinants reveal extensive structural similarities, and new homologs of bacterial glutamate receptors strengthen the evolutionary link between glutamate receptors and K+ channels.
LBR bears extensive structural similarities with the members of the sterol reductase family (ERG24p and ERG4p).
There are extensive structural similarities between the epithelial surfaces of the palatine tonsil and the cervix and comparative functional analyses will be highly informative in developing a comprehensive understanding of the primary events underlying C. albicans colonization.
There are also extensive structural similarities between the principal biogenesis proteins from both systems.
However, the complexity of the ubiquitin system causes considerable challenges for high-throughput drug discovery because of extensive structural similarities.
Sequence analysis suggests that RUNX3 is the evolutionary founder of the mammalian RUNX family [ 43], and there exists extensive structural similarities between the three mammalian RUNX genes.
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Together, these studies provide strong evidence that the K2P channel pore shares extensive structural similarity with the open pore structure of Kv channels, and are also consistent with the principal finding of the blocker access studies, that is, that the bundle crossing is 'open', even when the channel is in its closed conformation.
The sequence similarity is reflected by extensive structural similarity between yeast and human Ubc9 (0.53 Å Cα rmsd, previously noted for other structures in [40]).
TopSearch perhaps finds highest similarity to PARP1 because of an extensive structural similarity of the protein domains, especially in the regions involved in ligand binding.
Consistent with our phylogenetic analysis, it is apparent that the MPPs show the most extensive structural similarity with the active GK.
Both NaStEP and H. vulgare inhibitor proteins share extensive structural similarity; the loop equivalent to the one mediating the interaction of the barley proteins is present in NaStEP but is longer and has four cysteine residues instead of two [ 65].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com