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The energetics of a related (but more limited) process of transient base pair opening in solvated DNA had been previously characterized using imino-proton exchange [15], [16] but the more extensive structural change associated with single base flipping had not been anticipated prior to the structural studies of M.HhaI.
The recombination via repeat sequences is believed to be responsible for extensive structural change.
Overall, however, amino acid changes in both influenza B virus lineages were less frequent than those in influenza A viruses sampled over a similar time period, with the H3N2 viruses showing more extensive structural change.
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The overall approach is designed to handle several challenges including extensive structural changes, large viewpoint differences, repetitive structure, illumination differences, and flat regions.
TFIIS also induces extensive structural changes in Pol II that would realign nucleic acids in the active center.
Following economic or demographic decline, many cities undergo extensive structural changes which often lead to large wasteland areas.
Semi-arid succulent thicket in South Africa has experienced extensive livestock-induced transformation, reflected in extensive structural changes and loss of biodiversity, biomass and soil carbon.
"But it raises a question as to whether this important role will be carried out to quite the same extent in future, given the current level of uncertainty about newco's role and the extensive structural changes taking place in the police sector".
The results of the triggered action can be manifold and range from smaller conformational changes to more extensive structural changes such as cage-to-cage transformations and self-sorting phenomena.
Likely related to this low robustness, extensive structural changes towards an E. coli-type P5 7/P15 17 subdomain as a canonical interaction site for tRNA 3′-CCA termini could not be coaxed into increased ribozyme activity.
The human spliceosome, reported to contain over 140 subunits [1], undergoes extensive structural changes during its reaction cycle in which large complexes dissociate and others associate.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com