Considerable knowledge of the molecular organization of class I HLA antigens has been attained through extensive structural analysis of these proteins and their genes.
The work describes the most extensive structural analysis of eIF4E in relation to potyvirus resistance.
A fundamental understanding of the underlying structural mechanisms behind the catalytic activity of this enzyme has been established through extensive structural analysis of bacterial UPPs, starting with E. coli UPP (EcUPP) [13] [16] and then the closely-related S. typhimurium homologue [17] [19].
Extensive structural analysis has demonstrated that the palm and thumb domains of actively copying DNA polymerases make continuous contact with the minor groove of the primer-template DNA over a full turn of the DNA double helix.
Extensive structural analysis and experimental validation illuminate key residues that propagate larger-scale structural rearrangements and transducer binding that, collectively, elucidate the structural determinants of KOP pharmacology, function, and biased signaling.
Escherichia coli and Salmonella enterica have served as important model systems for extensive genetic, biochemical, and structural analysis of the flagellum, providing unparalleled insights into its structure, function, and gene regulation.
Extensive genetic, biochemical and structural analysis of this helix would likely provide a wealth of information concerning translational fidelity and subunit association.
The Tannenbaum laboratory has previously conducted extensive research on the chemistry and structural analysis of biological polymers, including proteins, nucleic acids, and polysaccharides.
Extended Data Fig. 1 Preliminary structural analysis of native lens Cx46/50 gap junction intercellular channels.
However, a more extensive structural MR analysis of the earliest site of AD, including the entorhinal cortex, amygdala, and hippocampus, as well as temporopolar and perirhinal regions, can ensure a higher specificity for distinguishing AD from subcortical vascular pathology (Braak et al 2006; Du et al 2006).
Sequence alignments show that residues in positions 67, 91, and 131 vary between isoforms and structural analysis of CA II in complex with various inhibitors, show that "tails" of inhibitors make extensive contacts with these residues.
