Sentence examples for extensive somatic mutations from inspiring English sources
A mitochondrial mutator phenotype has been proposed to account for the accumulation of extensive somatic mutations in clinical tumors [ 17].
Clustering of extensive somatic mutations in the variable region of an immunoglobulin heavy chain gene from a human B cell lymphoma.
LCLs seem most appropriate as a model for chemotherapeutic toxicity and, to some extent, chemotherapeutic response, although they do not contain the extensive somatic mutations known to be present in tumors.
Tumour cells derived from germinal- to postgerminal-centre B cells such as those of follicular lymphoma and multiple myeloma have shown extensive somatic mutations (Bahler and Levy, 1992; Bakkus et al, 1992; Zelenetz et al, 1992; Sahota et al, 1996).
Thus, genomic analysis performed using NGS provides extensive information about somatic mutations.
In contrast, HO is a potent mutagen that may cause mtDNA damage and copy number depletion under subtoxic conditions; these active responses to DNA damage provide a new explanation to the accumulation of extensive mtDNA damage and somatic mutations in clinical tumors and aging tissues under physiological and/or pathological conditions [ 11, 17].
Significantly mutated genes (SMGs) were defined as the somatic mutations with higher mutated frequency than background mutation rate.
Extended Data Fig. 3 Somatic mutations in solitary sampling.
Motivation: High-throughput sequencing of tumor samples has shown that most tumors exhibit extensive intra-tumor heterogeneity, with multiple subpopulations of tumor cells containing different somatic mutations.
More extensive biochemical and molecular studies will be necessary to determine the pathological significance of these somatic mutations.
Annotations were extensive and included an effect on protein coding sequence, population frequency, frequency in PCGP and the Catalogue Of Somatic Mutations In Cancer (COSMIC; http://cancer.sanger.ac.uk/cosmic) and various functional predictions.
