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Conventional medical management, however, remains frustrating for both patients and clinicians owing to poor specificity of pharmacotherapy, delayed onset of analgesia and extensive side effects.
In addition, high dose re-irradiation will have extensive side effects.
Such vaccination is, however, often accompanied by extensive side effects, in particular allergic reactions to the vaccine preparation that contains unmodified allergen(s).
However, these agents are associated with extensive side effects and long-term survival, as well as remission duration are still poor.
One disadvantage of this system is that the ligand, RU486, has been shown to interfere with other biological pathways (at a much higher concentration of ligand), so long term usage could have extensive side effects [ 9].
Multidrug-resistant strains of Acinetobacter baumannii plague soldiers wounded in the Middle East, and colistin, an older antibiotic with toxic side effects, remains a treatment of last resort due to extensive side effects.
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Finally, the well-documented and extensive side effect profiles of glucocorticoids, inclusive of immunotoxicity, growth stunting and effects on pituitary function, were not seen with VBP15 at doses up to nine times prednisolone dosing.
"Reading this, a potential mother-to-be may well not realise the severe and extensive potential side effects that this drug can have".
Novel targets for the management of HIV infection have become increasingly relevant in view of extensive drug resistance, side effects and high pill burden of some of the conventional anti-retroviral agents.
The experience with irAEs associated with ipilimumab therapy in CRPC is limited to phase 1 and 2 data, but the agent's clinical development in melanoma has provided more extensive characterization of side effects and how to proactively manage them 22, 23.
Thus, patient education materials should provide extensive information describing chronic side effects.
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