Interestingly, however, the C-terminal sequences responsible for activation of CA9 or PHD3 were not congruent between the HIF- α isoforms, with more extensive sequences being required for the activation of CA9 by HIF-1 α sequences.
A large number of genetic variants of uncertain functional significance have been identified due to the extensive sequencing being carried out, diluting the practical application of this valuable information [ 17, 18].
While in the present analysis, extensive sequencing was applied retrospectively only, genomic diversity of K. pneumoniae isolates from patients and environmental samples clearly indicated that the duration and extent of the outbreak had been underestimated.
Our new 2-D color visualization representing AT and CG skews was used, as described in methods, to draw the BSDT pictures (see Methods and Figure 1) for 379 chromosomes of 19 fully sequenced species and two bird species for which extensive genomic scaffold sequences were available.
Sequences similar to the piggyBac open reading frame have been identified in all animal species for which extensive genomic sequences are available, including the human.
The most significant and extensive of these sequences is his correspondence with Felix Frankfurter which spans the years 1928 to Frankfurter's death in 1965.
Proteins having extensive internal repeat sequences are not well tolerated by Escherichia coli, hence the use of less than full-length versions here (MWrmfp-1 = 14KDa vs MWmfp-1 = 92KDa).
Downstream of the signal peptide sequence at the N-terminus, is a sequence region (variable domain 1), in which extensive sequence variations are found among parasite species.
The advents of new high-throughput sequencing technologies, which produce extensive sequence data, are providing new opportunities to increase the amount of molecular markers, as demonstrated in the sturgeon, where hundreds of SNPs were discovered [ 44].
Fortunately, such extensive parallel sequencing is easily achievable using current technologies.
